Nokia licensee HMD Global is expected to launch the much-anticipated Nokia 9 flagship next month, with an event in China said to be the venue. The refresh of the Nokia 6, being referred to as the Nokia 6 (2018), is expected to be launched alongside. Both rumoured smartphones have been the recipients of numerous leaks, including a TENAA listing for the latter, cheaper offering that left virtually no detail to the imagination. Now, a Nokia Camera app build spotted in the Android Oreo beta for the Nokia 5 has tipped the upcoming use of a new type of dual camera setup expected to be seen on the Nokia 9 – a wide-angle lens coupled with a telephoto lens.
Spotted by Nokiamob.net, the Nokia Camera v8.0200.20 app on the Nokia 5 Android 8.0 Oreo beta build was torn down, and showed telephoto lens options up to 2x zoom, and wide-angle lens options (seen below). Alongside, more manual settings have been added: users will be able to adjust shutter speed between 1s and 1/500s, and choose from ISO 100 to 2,000. This is being thought to mean that Nokia has chosen to forego the RGB/ monochrome dual camera setup it used on the Nokia 8, and brought two RGB sensors with different fields of view and zoom capabilities on an upcoming smartphone – probably the Nokia 9.
Photo Credit: Nokiamob.net
The Nokia 9 and Nokia 6 (2018) were most recently in the news for reportedly being spotted on 3C – a Chinese certification authority. The 3C certification of the Nokia 9 and Nokia 6 (2018) didn’t reveal any details on the part of their specifications. The Nokia 9 is said to be listed with model number TA-1042, whereas the Nokia 6 (2018) has been spotted as TA-1054. There is also a speculation that the Nokia 9 will come in two other variants with model numbers TA-1005 and TA-1009.
Earlier this month, the Nokia 6 (2018) reportedly received TENAA certification in China – with a matching model number of TA-1054. Some early rumours claimed that the smartphone will have a similar design language as the Nokia 7 and will come with an 18:9 display. Also, it is expected to have a Qualcomm Snapdragon 630 SoC, coupled with 4GB RAM and 32GB onboard storage, and a dual camera setup on the back with the company’s iconic Bothie feature. The Nokia 9 and Nokia 6 (2018) are expected to be launched at a January 19 event in China.
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A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. Now scientists have found that insights into a rare genetic disease known as NGLY1 deficiency could help scientists understand how that resistance works — and potentially how drugs can outsmart it.
A protein called Nrf1 (shown in white in these mouse cells) can hamper promising drugs for blood cancers, but now researchers have found a possible workaround to shut Nrf1 down.
Credit: The American Chemical Society
A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance. Now scientists, reporting in ACS Central Science, have found that insights into a rare genetic disease known as NGLY1 deficiency could help scientists understand how that resistance works — and potentially how drugs can outsmart it.
A class of compounds called proteasome inhibitors that include bortezomib and carfilzomib — both approved by the U.S. Food and Drug Administration — have been effective at treating certain types of blood cancers. The drugs work by jamming some of cancer cells’ machinery to induce cell death. But the drugs have been limited by cancer cells ability to development resistance, as well as the inhibitors inability to fight solid tumors effectively. Studies have suggested that resistance could be linked to a protein called Nrf1. When proteasome inhibitors go into action, Nrf1 is spurred into overdrive to restore the cells’ normal activities and keep them alive. If researchers could figure out how to block Nrf1, they might be able to address the resistance problem. Carolyn Bertozzi and colleagues, through studying NGLY1 deficiency, a seemingly unrelated condition, may have hit upon an approach to do this.
The researchers were investigating how lacking the enzyme NGLY1 causes a host of debilitating symptoms. They found that NGLY1 is responsible for activating Nrf1, the protein that is suspected of weakening proteasome inhibitors’ effectiveness against cancer. Further testing showed that dampening NGLY1 allowed a proteasome inhibitor to continue doing its work killing cancer cells without interference from Nrf1. This finding, the authors note, holds great promise for the development of combination therapeutics for blood cancers in the future.
Every aspiring entrepreneur would love to be the next Mark Zuckerberg or Jeff Bezos, but most have no idea what really sets these guys apart from all the rest. Conventional wisdom has them looking for a painful problem, a very large opportunity, and minimal competitive barriers to entry. In reality, most great entrepreneurs find these necessary, but not sufficient for the big win.
They think outside the box, with a sometimes surprising set of strategies, as outlined in a new book, “Think Bigger,” by Michael Sonnenfeldt. He has collected in-the-trenches intelligence and lessons from his TIGER 21 group of over 500 entrepreneurs and executives around the world. Each has amassed $10 million or more in personal assets, and is willing to share their insights with others.
Sonnenfeldt presents a rich array of strategies in his forty lessons from the trenches, including the following paraphrased insights that I find often overlooked or even rejected, based on my years of experience mentoring entrepreneurs:
- Experience at a first-rate company is really valuable. Good big companies provide the training, mentoring, and experience managing teams that entrepreneurs need, but can’t afford. In addition, you can learn much about business principles, and your own capabilities, from being surrounded by many intense, ambitious, and super-smart peers.
- Entrepreneurship is rarely about just making money. The best entrepreneurs are committed to fixing a problem, or advancing a purpose, and making money is only used as a validation of their insight. Any money made is typically poured back into the cause, rather than relished for a high-class lifestyle or extravagances by the entrepreneur.
- Self-control beats passion for long term satisfaction. Passion often leads to a need for instant gratification. Most successful entrepreneurs either learn or are born with the capacity to delay gratification for critical periods in their lives. Even after success, they use self-control to continue to live modestly, and plow their profits back into business.
- Think twice before investing with friends and family. Some are so self-centered that they see family and friends as an easy source of capital. Smarter entrepreneurs know that nothing can bring more embarrassment, resentment, and peril to relationships with people you love and respect than losing their money. Don’t jeopardize key relationships.
- You are never to smart or too old for a mentor. In case you think mentors are only for “wimps,” you should know that Bill Gates always revered the guidance he received from Warren Buffet on many corporate matters. Most successful business people, whether retired or still active, love to share the wisdom they gained from their own experience.
- Entrepreneurial skills can limit investing success. Entrepreneurs and investors are different kinds of people, inside and out. Smart investors diversify their exposure across multiple assets; if any one of these fails, they are still in the game. A true entrepreneur makes one big bet on a new and untested asset, normally against conventional wisdom.
- Apply business skills to solve social problems. Social entrepreneurship is on the rise, with the advent of Millennials and a total world view. Companies that pursue socially relevant goals as part of their mission have the potential to generate double-bottom-line results – a financial return as well as a social benefit. One plus one can now equal three.
- Skip conservative – be optimistic, even delusional. The best entrepreneurs just believe they can make it happen – even though conventional logic would peg the risk as being off the charts. Professional investors dismiss founders who give “conservative” financial projections, and usually make less. Shoot for the moon – you may hit it.
- Surround yourself with people who are smarter than you. Too many entrepreneurs have a tendency to overrate their personal skills and wisdom, and seek out people who won’t challenge them. The smartest ones acknowledge their weaknesses, and find people who complement their skills, from whom they can learn and delegate authority.
- Resilience and determination generally beat IQ. We all know of successful businesses started by entrepreneurs who dropped out of school, while MBAs get no premium with investors. According to most experts, “street smarts” (experience) trump “book smarts” (intelligence) every time, especially if accompanied with a large dose of grit.
Whether you are already a seasoned entrepreneur, or just starting out, I recommend that you regularly strive to think bigger and outside the box, starting with the lessons from others who have been there and done that, and emerged successfully. We need you then to contribute to the next set of winning strategies for the next generation of entrepreneurs.
Coolpad is all set to unveil the Cool Play 6 in India on August 20. The smartphone was launched in China back in May for a price of 1,499 Yuan which roughly translates to around Rs 15,000. The smartphone was heavily marketed as a gaming smartphone in China and was launched in two color options – namely Soft Gold and Black.
Coolpad has been teasing the launch of the Play 6 on its Facebook page with the tagline “Livetoplay” and posts such as “6 is not just a number anymore! It is a new era and new benchmark. Monster is all set for 20th Aug. The thrilling power, the invincible. Stay tuned to know more. #LiveToPlay”.
The Play 6 is set to compete with the likes of the Moto G5 Plus and Xiaomi Redmi Note 4. It comes with a metal unibody design, a dual camera setup at the rear, the latest version of Android and fairly high end hardware for the price.
The Play 6 is powered by the Qualcomm Snapdragon 653 processor paired with 6GB of RAM and a 4,060mAh battery that the company claims can deliver 252 hours of standby time, 9 hours of internet browsing, 8 hours of video watching and 6 hours of gaming.
Additionally, the Play 6 comes with a 5.5-inch Full HD display with a resolution of 1080 x1920, 64GB of internal storage expandable via a miscroSD card, a rear mounted fingerprint scanner and a USB Type C port for charging and data transfer. It supports 4G LTE, dualSIMs, Wi-Fi, Bluetooth, and GPS.
On the imaging front, the Cool Play 6 comes with a dual camera setup at the rear – a primary 13MP RGB (color) sensor paired with a secondary 13MP monochrome (black and white) sensor with a dual-LED flash. Both sensors have an aperture of f/2.0. The secondary sensor allows for the capture of images with depth of field information. On the front, there is an 8MP sensor with an aperture of f/2.2 for selfies.