Biocon shares gain over 2% on launch of cancer drug KRABEVA in India

Biocon share price gained 2.5 percent intraday Thursday after the biopharmaceuticals firm has launched KRABEVA, a biosimilar Bevacizumab, in India.

The drug is used for the treatment of patients with metastatic colorectal cancer and other types of lung, kidney, cervical, ovarian and brain cancers, in India.

“We believe KRABEVA will be an important addition to oncology portfolio of novel biologics as well as biosimilars, which are making a significant impact in the realm of cancer care in India,” Arun Chandavarkar, CEO and joint MD, Biocon said.

KRABEVA is the second key oncologic biosimilar product from Biocon’s global biosimilars portfolio to be launched in India, in order to address the unmet patient need for affordable biological therapies.

The product is being offered to patients at an MRP of Rs 24,000 for 100 mg / 4 ml vials and Rs 39,990 for 400 mg / 16 ml vials.

KRABEVA is being launched post successful completion of phase III clinical trials and approval of company’s marketing authorisation application by the Drug Controller General of India.

At 11:02 hours IST, the stock price was quoting at Rs 418.50, up Rs 9.90, or 2.42 percent on the BSE.

source:-.moneycontrol.

Biocon climbs 2.65% on launch of cancer medicine

Shares of Biocon jumped as much as 2.65 per cent in Tuesday as the company has launched its cancer biosimilar drug KRABEVA in India.

Following a positive open at Rs 410 against the previous close of Rs 408.60, the scrip touched an intraday high of Rs 419.75 and a low of Rs 405.80. In terms of equity volume, 10.29 lakh shares traded on the BSE.

The stock ended the session up by 1.09 per cent at Rs 413.05.

According to a BSE filing, the biosimilar product will be used for the treatment of patients with metastatic colorectal cancer and other types of lung, kidney, cervical, ovarian and brain cancers in India.

Biocon CEO and Joint MD Arun Chandavarkar said: “With KRABEVA, we intend to provide a high quality, world-class biosimilar Bevacizumab as an affordable therapy option for patients of various types of cancer.”

The company believes that the product will be an important addition to its oncology portfolio of novel biologics as well as biosimilars, which are making a significant impact in the realm of cancer care in India, he added.

Source:-thehindubusinessline

Girl, 13, Begged Father For Money To Treat Cancer. Video Viral After Death

Girl, 13, Begged Father For Money To Treat Cancer. Video Viral After Death

Sai Shri’s parents had been separated for eight years and she had been living with her mother

“Daddy…please do something and save me” – says a 13-year-old girl in an incredibly tragic WhatsApp video to her father, begging him for money for her cancer treatment. Young Sai Shri died on Sunday in Andhra Pradesh’s Vijayawada, but her tearful voice is being heard by thousands through the video that has been widely shared online.

Sai Shri’s parents had been separated for eight years and she had been living with her mother. In the video, she pleads with her father, Shetty Shivakumar, to sell her home – which was in her name – to raise money for her treatment. Her mother had reportedly tried to sell the house but was stopped by her father, who allegedly got help from a politician to try and throw his estranged family out.

Sai was diagnosed with cancer in August, and doctors reportedly told her mother that a bone marrow transplant was the only option.

Speaking in Telugu in the excruciating video, she shows swellings and lesions on her arms and legs and shares that she is in great pain.

“Daddy, you say that you don’t have money. At least we have this house. Please sell this house and pay for my treatment daddy. Or else, they (doctors) say that I won’t survive for long,” she weeps.

“I haven’t gone to school in months. I want to play with my friends…I want to go to school…take my exam…I want to become a doctor…”

Based on a complaint by an activist, the Andhra Pradesh State Human Rights Commission has asked the police to investigate whether Mr Shivakumar, who lives in the same city, was guilty of neglecting his daughter.

Activists allege that Mr Shivakumar refused to spend money for his daughter’s treatment even though he could afford it.

Sai’s mother Sumashri had reportedly spent Rs. 30 lakh but the treatment was not good enough for the type of cancer that she was suffering from.

[“source-ndtv”]

6 Newly discovered Proteins may additionally assist combat Alzheimer’s, cancer

6 Newly Found Proteins May Help Fight Alzheimer's, Cancer

The analysis uncovered the genes for 6 new proteins, which were dubbed small humanin-like peptides, or SHLPs, 1 via 6. (Representational photograph)
WASHINGTON: Scientists have determined a set of six new proteins that could help disclose secrets and techniques of ways we age, doubtlessly unlocking new insights into diabetes, Alzheimer’s, cancer anddifferent growing olderrelated illnesses.

The tiny proteins appear to play numerous big roles in our bodies‘ cells, from decreasing the quantity ofdamaging loose radicals and controlling the charge at which cells die to boosting metabolism and assistingtissues at some point of the frame respond better to insulin, researchers stated.

The obviously occurring amounts of every protein decrease with age, main researchers to trust that they play an crucial position inside the growing old procedure and the onset of diseases connected to older age, they stated.

The studies crew led by means of Pinchas Cohen, professor at the university of Southern California Leonard Davis faculty of Gerontology, recognized the tiny proteins for the first time and located theirsudden beginning from organelles in the mobile referred to as mitochondria and their sportchangingroles in metabolism and mobile survival.

The contemporary locating builds upon earlier studies by Cohen and his group that exposed two greatproteins, humanin and MOTS-c, hormones that appear to have huge roles in metabolism and sicknesses ofgrowing older.

in contrast to most other proteins, humanin and MOTS-c are encoded in mitochondria, the structure insidecells that produces power from food, in preference to inside the mobile‘s nucleus in which maximumgenes are contained.

Mitochondria have their personal small collection of genes, which have been as soon as concept to playhandiest minor roles inside cells however now seem to have essential functions all through the body.

Cohen’s crew used computer analysis to peer if the a part of the mitochondrial genome that offers the code for humanin become coding for other proteins as well.

The evaluation uncovered the genes for 6 new proteins, which have been dubbed small humanin-like peptides, or SHLPs, 1 thru 6.

After figuring out the six SHLPs and effectively developing antibodies to check for numerous of them, thegroup examined both mouse tissues and human cells to decide their abundance in exceptional organs in addition to their functions. The proteins have been dispensed quite in another way amongst organs, which indicates that the proteins have varying features based on where they’re inside the frame.

Of specific hobby is SHLP 2, Cohen stated. The protein appears to have profound insulin-sensitising, anti-diabetic effects in addition to effective neuro-shielding activity which could end up a approach to fightAlzheimer’s disease. He added that SHLP 6 is also interesting, with a completely unique potential to sellmost cancers mobile demise and therefore potentially target malignant sicknesses.

“The findings are an important advance to be able to be ripe for fast translation into drug improvement forsicknesses of getting old,” said Cohen.

(This tale has not been edited by means of NDTV staff and is car-generated from a syndicated feed.)